I can attest to NOD running on Trex 7.1 patch lvl 60 (and a failed PL 61 and SAP recommending we roll back) would cause issues with indexing overall and caused drives to blow out due to multiple 80+ GB txt files being created due to Trex not being able to access the main indexes to place the new indexed data into.
Still till this point we haven't found a solution to the issue, and the Trex systems themselves haven't had a hiccup.